GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs9473555 | 1 | rs6458690 | chr6:49411619 | MUT | chr6:49398994-49431031:- | 0.28 | 9.74 | 1.42E-20 | Folate pathway vitamin levels |
| THCA | cis | rs9473555 | 1 | rs6458694 | chr6:49445306 | CENPQ | chr6:49431096-49460820:+ | -0.27 | -5.52 | 5.46E-8 | Folate pathway vitamin levels |
| THCA | cis | rs9473555 | 1 | rs6458694 | chr6:49445306 | MUT | chr6:49398994-49431031:- | 0.28 | 9.69 | 2.1E-20 | Folate pathway vitamin levels |
| THCA | cis | rs7762018 | 1 | rs6459657 | chr6:170136454 | C6orf70 | chr6:170151721-170181617:+ | 0.26 | 5.27 | 2.11E-7 | Thiazide-induced adverse metabolic effects in hypertensive patients |
| THCA | cis | rs7762018 | 1 | rs6459657 | chr6:170136454 | WDR27 | chr6:169857307-170102159:- | -0.17 | -5.28 | 1.92E-7 | Thiazide-induced adverse metabolic effects in hypertensive patients |
| THCA | cis | rs2243480 | 1 | rs6460260 | chr7:65215455 | CCT6P1 | chr7:65216092-65228661:+ | -0.42 | -6.66 | 7.61E-11 | Diabetic kidney disease |
| THCA | cis | rs2243480 | 1 | rs6460260 | chr7:65215455 | CRCP | chr7:65579805-65619551:+ | 0.31 | 4.7 | 3.45E-6 | Diabetic kidney disease |
| THCA | cis | rs2243480 | 1 | rs6460260 | chr7:65215455 | RABGEF1 | chr7:66093890-66276446:+ | -0.53 | -6.54 | 1.58E-10 | Diabetic kidney disease |
| THCA | cis | rs2243480 | 1 | rs6460261 | chr7:65215580 | CCT6P1 | chr7:65216092-65228661:+ | -0.42 | -6.66 | 7.61E-11 | Diabetic kidney disease |
| THCA | cis | rs2243480 | 1 | rs6460261 | chr7:65215580 | CRCP | chr7:65579805-65619551:+ | 0.31 | 4.7 | 3.45E-6 | Diabetic kidney disease |
| THCA | cis | rs2243480 | 1 | rs6460261 | chr7:65215580 | RABGEF1 | chr7:66093890-66276446:+ | -0.53 | -6.54 | 1.58E-10 | Diabetic kidney disease |
| THCA | cis | rs2243480 | 1 | rs6460274 | chr7:65628484 | CCT6P1 | chr7:65216092-65228661:+ | -0.42 | -6.7 | 5.9E-11 | Diabetic kidney disease |
| THCA | cis | rs2243480 | 1 | rs6460274 | chr7:65628484 | CRCP | chr7:65579805-65619551:+ | 0.3 | 4.63 | 4.66E-6 | Diabetic kidney disease |
| THCA | cis | rs2243480 | 1 | rs6460274 | chr7:65628484 | LOC493754 | chr7:65993446-66057363:- | -0.29 | -3.36 | 0.000833 | Diabetic kidney disease |
| THCA | cis | rs2243480 | 1 | rs6460274 | chr7:65628484 | RABGEF1 | chr7:66093890-66276446:+ | -0.57 | -7.14 | 3.42E-12 | Diabetic kidney disease |